Two US troops and an American civilian were killed in central Syria on Saturday after an alleged member of the Islamic State group opened fire on a joint US-Syrian patrol, officials said.

US Central Command (CENTCOM) announced the deaths on X after Syria's state media earlier reported that an attack in the city of Palmyra had wounded American and Syrian troops.

"An ambush by a lone ISIS gunman" resulted in the deaths and injuries to three additional troops, said CENTCOM, which oversees the US military in the Middle East.

"The gunman was engaged and killed," it said.

Pentagon spokesman Sean Parnell said the attack occurred as the soldiers"were conducting a key leader engagement" in support of counter-terrorism operations, while US envoy to Syria Tom Barrack said the ambush targeted"a joint US-Syrian government patrol."

"The savage who perpetrated this attack was killed by partner forces," US Defence Secretary Pete Hegseth wrote on X.

Parnell said the identities of the deceased troops would be withheld until after their families were notified.

The incident is the first of its kind reported since Islamist-led forces overthrew longtime Syrian ruler Bashar al-Assad in December last year, and rekindled the country's ties with the United States.

A Pentagon official, speaking on the condition of anonymity, said the attack"took place in an area where the Syrian President does not have control."

Syrian state news agency SANA, quoting a security source, earlier reported that several US troops and two Syrian service members had been wounded in the attack.

A 'joint field tour' in Palmyra

The soldiers were taking part in a"joint field tour" in Palmyra, which was once under the control of the Islamic State (IS) group, SANA reported.

A Syrian military official who requested anonymity said that the shots were fired"during a meeting between Syrian and American officers" at a Syrian base in Palmyra.

A witness, who asked to remain anonymous, said he heard the shots coming from inside the base.

According to the Syrian Observatory for Human Rights monitor, which has a wide network of sources inside Syria, the meeting came as part of an"American strategy to strengthen its presence and foothold in the Syrian desert".

Helicopters evacuated the wounded to the Al-Tanf base in southern Syria, where American troops are deployed, SANA said.

'Prior warnings'

Last month, during Syrian President Ahmed al-Sharaa's visit to Washington, Damascus formally joined the US-led global coalition against the IS group.

US forces are deployed in Syria's Kurdish-controlled northeast as well as at Al-Tanf near the border with Jordan.

Syria's interior ministry said Saturday that it had warned the US-led coalition of a possible breach by Islamic State (IS) group fighters, following a deadly attack on American troops in Palmyra.

Watch moreA new Syria? One year after the fall of Bashar al-Assad

"There were prior warnings from the internal security command to allied forces in the desert region," ministry spokesman Anwar al-Baba said in an interview on state television.

"The international coalition forces did not take the Syrian warnings of a possible IS infiltration into consideration," he added.

Syria's foreign minister condemned the attack. Damascus"strongly condemns the terrorist attack that targeted a joint Syria-US counterterrorism patrol near Palmyra", said Asaad al-Shaibani in a post on X.

"We extend our condolences to the families of the victims, as well as to the American government and people, and wish the wounded a speedy recovery."

US President Donald Trump said that “there will be very serious retaliation” after two US service members and one American civilian were killed in an attack in Syria that the United States blames on the Islamic State group.

“This was an ISIS attack against the US, and Syria, in a very dangerous part of Syria, that is not fully controlled by them,” he said in a social media post.

The American president told reporters at the White House that Syria's president, Ahmed al-Sharaa, was “devastated by what happened” and stressed that Syria was fighting alongside US troops. Trump, in his post, said al-Sharaa was “extremely angry and disturbed by this attack.” Trump said the three “seem to be doing pretty well.” The US military said the gunman was killed.